A Few To A Greater Extent Than Words Virtually Practiced Brains Together With Bad Brains



My previous Good Brain / Bad Brain post service may conduct maintain been a lilliputian out there, then hither are 4 brief comments.

(1) HCP database.  The entire Human Connectome Project database (ConnectomeDB) is an amazing resources that's freely available (more details inwards Van Essen et al., 2013, 2015).


(2) Good reporting / bad reporting.  Smith et al. (2015) are to hold upwards commended for such an impressive trunk of work.1  But I yet call back it was remiss to study a population along a judgmental good/bad binary axis inwards a cursory manner. The correlation/causation conundrum needs to a greater extent than of a caveat than:
These analyses were driven yesteryear too study exclusively correlations; inferring too interpreting the (presumably complex too diverse) causalities remains a challenging number for the future.
...or else you're confronted alongside press coverage like this:
Are approximately brains wired for a lifestyle that includes teaching too high levels of satisfaction, acre others are wired for anger, rule-breaking, too marrow use?

“Wired” implies born that way no effects of living inwards poverty inwards a shitty neighborhood.

Oh, too my flippant observation most the vino cooler/malt liquor axis wasn't genuinely a major instrumentalist inwards the canonical correlation analysis. But race too ethnicity information was indeed collected (but non used: “partly because the race stair out is non quantitative, just consists of several distinct categories”).


(3) Ethics!  This brings upwards the larger number of ethics. Influenza A virus subtype H5N1 whole host of personal player information (e.g., genomics from everyone, including hundreds of identical twins) is included inwards the package. From Van Essen et al. (2013):
The released HCP information are non considered de-identified, insofar every bit sure enough combinations of HCP Restricted Data (available through a dissever process) mightiness let identification of individuals every bit discussed below. It is accordingly of import that all investigators who concord to Open Access Data Use Terms consult alongside their local IRB or Ethics Committee to create upwards one's heed whether the question needs to hold upwards approved or declared exempt. If needed too upon request, the HCP volition render a certificate stating that an investigator has accepted the HCP Open Access Data Use Terms. Because HCP participants come upwards from families alongside twins too non-twin siblings, there is a adventure that combinations of information most an private (e.g., historic menstruum yesteryear year; trunk weight too height; handedness) mightiness atomic number 82 to inadvertent identification, specially yesteryear other household unit of measurement members, if these combinations were publicly released.

Oops.

Important Notice to Recipients too System Administrators of HCP Connectome In Influenza A virus subtype H5N1 Box Hard Drives

Thank you lot for acquiring a Connectome-in-a-Box that contains HCP icon data.  This provides an slow too efficient way to transfer large HCP datasets to other labs too institutions wanting to procedure lots of data, especially when multiple investigators are involved. With it comes a require to insure compliance alongside HCP’s Data Use Terms every bit good every bit whatever institutional requirements.


And whatever player inwards the study tin await at the results too infer, because of their regular cannabis job too their father's history of heavy drinking, that they must conduct maintain a “bad brain.” Do the investigators conduct maintain an obligation to counsel them on what this mightiness hateful (and what they should do)? Yeah, halt smoking cigarettes too pot, just there's non much they tin produce most their father's marrow abuse or their fluid intelligence.


(4) Biology.  Finally, I'm non sure enough what the finding agency biologically. Across a population, there's a full general mode of functional connectivity acre participants prevarication inwards a scanner alongside nix to do. That falls along an axis of “positive” too “negative” traits. And this designing of correlated hemodynamic activity across xxx node-pair edges means....... what, exactly?

Every person's connectome is unique (“The Neuroscience of Immortality, which caused quite a splash).

What is the human relationship betwixt resting solid set down functional connectivity too the implementation of idea too deportment via neural codes? This must hold upwards exceptionally unique for each person. We know this because fifty-fifty inwards lowly organisms similar flies, neurons inwards an olfactory percentage called the mushroom bodies show a striking marking of individuality inwards neural coding across animals.3 
At the single-cell level, nosotros demonstrate that uniquely identifiable MBONs [mushroom trunk output neurons, n=34] display profoundly dissimilar tuning across dissimilar animals, just that tuning of the same neuron across the 2 hemispheres of an private wing was nearly identical.

In other words, a fly's unique olfactory sense shapes the answer properties of a tiny fix of neurons, fifty-fifty for animals reared nether the same conditions. “In several cases, nosotros fifty-fifty recorded on the same hateful solar daytime from progeny of the same cross, raised inwards the same nutrient vial” (Hige et al., 2015).

Fig. 5c (Hige et al., 2015).


I never know what to produce alongside information similar this, especially inwards the context of human brains, skilful too bad.....  Maybe: Are approximately wing MBONs wired for a wild lifestyle of apple tree cider vinegar?





Footnotes

1 Or perchance the resultant was a massive illustration of confirmation bias, every bit suggested inwards a private comment to me.

2 See this book review for an opposing view.

3 fly newspaper via @fly_papers (also @debivort too @neuroecology).

4 Also run into Neurocriminology inwards prohibition-era New York.


Sumber http://neurocritic.blogspot.com/

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